RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
E2F1
RNA ID
RNA Type
mRNA
Alteration Pattern
up regulation
Species
homo sapiens
Detection Methods
luciferase report assay;immunoprecipitation
Target
CCNE2
Pathway
NA
PubMed ID
Title
E2F transcription factor 1 (E2F1) promotes the transforming growth factor TGF-beta1 induced human cardiac fibroblasts differentiation through promoting the transcription of CCNE2 gene
Year
2021
Function
"E2F1 and its downstream target gene CCNE2 play a vital role in TGF-beta1-induced HCFs differentiation, thus E2F1 and CCNE2 may be a potential therapeutic target for cardiac fibrosis."